![]() Selected numbers of vials from each type were then exposed to "25 ☌ and "2 ☌ for 24-hour periods.įINDINGS: There was complete concordance between HCWs and phase-contrast microscopy in identifying freeze-damaged vials and non-frozen samples. A total of 475 vials of 8 different types of World Health Organization prequalified freeze-sensitive vaccines from 10 different manufacturers were used. METHODS: A double-blind crossover design was used to compare the performance of the shake test conducted by trained health-care workers (HCWs) with that of phase contrast microscopy as a "gold standard". OBJECTIVE: To determine the validity of the shake test for detecting freeze damage in aluminium-based, adsorbed, freeze-sensitive vaccines. IVNational Institute of Hygiene, Warsaw, Poland IIIGlobal Influenza Programme, World Health Organization, Geneva, Switzerland ![]() IIEmergency Department, Karaman Hayat Medical Centre, Karaman, Turkey IDepartment of Immunization, Vaccines and Biologicals, World Health Organization, 20 Avenue Appia, 27 Geneva 1211 Switzerland ![]() Ümit Kartoglu I, * Nejat Kenan Özgüler II Lara J Wolfson III Wiesław Kurzatkowski IV Validación de la prueba de agitación para detectar daños por congelación en las vacunas adsorbidas Validation de l'épreuve d'agitation pour la détection des dommages occasionnés aux vaccins adsorbés Validation of the shake test for detecting freeze damage to adsorbed vaccines
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